Endocrine Abstracts

Background: Primary hyperparathyroidism (PHPT) is a common endocrine disorder accompanied by high cytokines and low total 25-hydroxyvitamin D [25(OH)D]. An inflammatory cytokine, monocyte chemoattractant protein-1 (MCP-1), is found to be higher in people with elevated parathyroid hormone (PTH), unlike other cytokines (1). Also, a rise in MCP-1 in response to high PTH is associated with bone loss (2). Parathyroidectomy (PTX) is the only cure for patients with PHPT. Whether the ...

Understanding the molecular factors that regulate human muscle mass is acquiring increasing scientific interest. Hitherto, known (+ve) endocrine regulators of lean body mass included the GH-IGF-1 system, anabolic steroids, and (−ve) myostatin. In order to elucidate this process further, we have investigated a clinical case at a genetic and phenotypic level. A 46-year-old man with idiopathic muscle hypertrophy requiring multiple therapeutic fasciotomies underwent clinical...